Now that J.D. (Zach Braff), Turk (Donald Faison) and Elliot (Sarah Chalke) are more familiar with the hospital and its procedures, they have an air of confidence and cockiness. But a rival intern Nick Murdoch (Sean Hayes of "Will & Grace"), also smart and well-liked shows them that being confident is sometimes a mask for pure fear. Because Nick is so nice and congenial, J.D. has a hard time disliking him. But things change when Nick can’t handle the pressures of dealing with a very sick patient and eventually drops out of the residency program. Turk (Donald Faison) has a confidence crisis when he freezes up during surgery. The love and support from Carla (Judy Reyes) and some self-love bring him back to normal.

Elliot tries to deny her moments of doubt but decides that sometimes she just needs to have a little cry in private. Meanwhile, Dr. Cox has his own problems when he introduces two patients to each other: one believes that he is Jesus Christ and the other believes that he is Satan.